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The second major complication is a steroid related rise in eye pressure, also known as being a "steroid responder".  This usually requires at least 2 weeks of continuous steroid use, and is reversible if the steroid is discontinued.  The rise in pressure can be very high but if often asymptomatic.  It may be more common in people already being treated for glaucoma. If a person has glaucoma or has a history of steroid related eye pressure problems, they should consult with an ophthalmologist for monitoring of eye pressure if steroid treatment is being contemplated.

The same MRC trial mentioned above also analyzed the effects of anagrelide on bone marrow fibrosis, a common feature in patients with myelofibrosis. The use of anagrelide was associated with a rapid increase in the degree of reticulin deposition (the mechanism by which fibrosis occurs), when compared to those in whom hydroxyurea was used. Patients with myeloproliferative conditions are known to have a very slow and somewhat variable course of marrow fibrosis increase. This trend may be accelerated by anagrelide. Interestingly, this increase in fibrosis appeared to be linked to a drop in hemoglobin as it progressed. Fortunately, stopping the drug (and switching patients to hydroxyurea) appeared to reverse the degree of marrow fibrosis. Thus, patients on anagrelide may need to be monitored on a periodic basis for marrow reticulin scores, especially if anemia develops, or becomes more pronounced if present initially. [6]

If I were to make a listing of all of the dog behaviors I like it would most likely be fairly long. A deliciously comfortable tail wag, a bow to solicit play, and a mushy sigh before resting their head in your lap would absolutely make the list. However, those are only a few of the numerous the explanation why canine deliver us immense pleasure each day. However, my list of canine behaviors that are not so favorable is slightly short. For me, like most, one of many few things on that checklist would surely be coprophagia. Coprophagia is the consumption of feces. This will embrace the feces of others as well as their own.

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