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Adverse reactions in the treatment Pulmozim are rare (<1/1000), in most cases are mild, are transient in nature and do not require dose adjustment. From the side of hematopoiesis: acute lymphocytic leukemia, aplastic anemia. From the nervous system: seizures, migraine. From the senses: conjunctivitis, disequilibrium. On the part of the cardiovascular system: tachycardia, bradycardia, cardiac arrest. On the part of the respiratory system: pneumonia, bronchitis, respiratory tract infection, including due of Pseudomonas, pharyngitis, laryngitis, voice alteration (hoarseness), dyspnoea, rhinitis, worsening of pulmonary function, reduced respiratory function, respiratory failure, hemoptysis, pneumothorax, pulmonary hemorrhage, polyp throat, cough, increased bronchial secretions, alveolitis, hypoxia, bronchospasm, productive cough. On the part of the gastrointestinal tract: dyspepsia, abdominal pain, bloody vomiting, liver failure. With the skin side and its appendages: rash, itching, hives, dermatitis, purpura, angioedema. pregnancy, postpartum: premature birth, complications during pregnancy, miscarriage, medical abortion. On the part of the body as a whole: . pleural chest pain, fever, fatigue, malaise, death Patients who develop adverse events that coincide with the symptoms of cystic fibrosis can usually continue using Pulmozim. Adverse events leading primobolan cycle to the complete cessation of treatment Pulmozim, observed in a very small number of patients, and the frequency of interruption of therapy was similar with placebo appointment (2%) and dornase alfa (3%). The antibodies to dornase alfa were found in less than 5% of patients, but none of them are not classified as IgE. Improved lung function was noted even after the appearance of antibodies to dornase alfa.