Oxymetholone toxicity

Systemic corticosteroids can reactivate tuberculosis and should not be used in patients with a history of active tuberculosis, except when chemoprophylaxis is instituted concomitantly. The incidence or course of acute bacterial infection are probably minimally affected by inhaled triamcinolone. Application of topical corticosteroids to areas of infection, including tuberculosis of the skin, should be initiated or continued only if the appropriate antiinfective treatment is instituted. If the infection does not respond to the antimicrobial therapy, the concurrent use of the topical corticosteroid should be discontinued until the infection is controlled.

Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are

They are the two most common and popular oral steroids of all time and for the purpose of bulking there are few that can come close to the power of Dianabol and Anadrol . Both of these very powerful steroids are often discussed together and in many circles you will find fans of both and often fans of Anadrol will swear up and down it is the more powerful of the two; however, this is simply not true. On a milligram for milligram basis Dianabol is far stronger than Anadrol; in-fact, its not that close; yes, both are very powerful but Dianabol takes first prize handedly. This common misconception regarding the two steroids exists for one very simple reason and that is common dosing protocol. Most all cycles that include Anadrol will start at 50mg per day with 100mg per day being very common place, while conversely most Dianabol cycles will start at 20-30mg per day and while they often go up to 50mg in more hardcore circles, for the average gym rat it is rare. You rarely hear of anyone supplementing with 100mg of Dbol per day outside of elite level bodybuilding but if an individual were to take both steroids, one during the first cycle and the other in a second cycle and at equal doses in both, assuming both forms were of pure quality and all other variables remained the same the gains made from Dianabol would shadow Anadrol into the ground. In the end, while Dbol is more powerful you must find what works best for you, find which you tolerate to a higher degree, regardless of power your personal toleration is of the utmost importance.

In clinical studies, cyproterone was found to be far less potent and effective as an antiandrogen relative to CPA, likely in significant part due to its lack of concomitant antigonadotropic action. [3] Cyproterone was studied as a treatment for precocious puberty by Bierich (1970, 1971), but no significant improvement was observed. [18] In men, 100 mg/day cyproterone proved to be rather ineffective in treating acne , which was hypothesized to be related to its progonadotropic effects in males and counteraction of its antiandrogen activity. [3] [19] In women however, in whom the drug has no progonadotropic activity, 100–200 mg/day oral cyproterone was effective in reducing sebum production in all patients as early as 2–4 weeks following the start of treatment. [3] In contrast, topical cyproterone was far less effective and barely outperformed placebo . [3] In addition, another study showed disappointing results with 100 mg/day cyproterone for reducing sebum production in women with hyperandrogenism . [3] Similarly, the drug showed disappointing results in the treatment of hirsutism , with a distinct hair reduction occurring in only a limited percentage of cases. [3] In the same study, the reduction of acne was better, but clearly inferior to that produced by CPA, and only the improvement in seborrhea was regarded as satisfactory. [3] The addition of an oral contraceptive to cyproterone resulted in a somewhat better improvement in acne and seborrhea relative to cyproterone alone. [3] According to Jacobs (1979), “[cyproterone] proved to be without clinical value for reasons that cannot be discussed here.” [20] In any case, cyproterone has been well-tolerated by patients in dosages of up to 300 mg/day. [3]

Oxymetholone toxicity

oxymetholone toxicity

In clinical studies, cyproterone was found to be far less potent and effective as an antiandrogen relative to CPA, likely in significant part due to its lack of concomitant antigonadotropic action. [3] Cyproterone was studied as a treatment for precocious puberty by Bierich (1970, 1971), but no significant improvement was observed. [18] In men, 100 mg/day cyproterone proved to be rather ineffective in treating acne , which was hypothesized to be related to its progonadotropic effects in males and counteraction of its antiandrogen activity. [3] [19] In women however, in whom the drug has no progonadotropic activity, 100–200 mg/day oral cyproterone was effective in reducing sebum production in all patients as early as 2–4 weeks following the start of treatment. [3] In contrast, topical cyproterone was far less effective and barely outperformed placebo . [3] In addition, another study showed disappointing results with 100 mg/day cyproterone for reducing sebum production in women with hyperandrogenism . [3] Similarly, the drug showed disappointing results in the treatment of hirsutism , with a distinct hair reduction occurring in only a limited percentage of cases. [3] In the same study, the reduction of acne was better, but clearly inferior to that produced by CPA, and only the improvement in seborrhea was regarded as satisfactory. [3] The addition of an oral contraceptive to cyproterone resulted in a somewhat better improvement in acne and seborrhea relative to cyproterone alone. [3] According to Jacobs (1979), “[cyproterone] proved to be without clinical value for reasons that cannot be discussed here.” [20] In any case, cyproterone has been well-tolerated by patients in dosages of up to 300 mg/day. [3]

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