Oxymetholone is as mentioned very hepatic and liver enzymes will necessarily increase dramatically with its use. For this reason most Oxymetholone use will generally need to be kept at 6 weeks max with many never needing to go beyond 4 weeks of total use. While this is a very short lived duration its important to note, Oxymetholone appears to be one of the few steroids that really diminishes after use is extended; meaning, even if you went past the 6 week mark you probably wouldnt get much out of it other than damaging your liver. It is comforting to note, while it is toxic to the liver, when used responsibly any toxic effect will be of little concern as the liver will quickly return to normal once use is discontinued. It is important to note, as this steroid is hepatic it does not carry near the level of hepatotoxicity as many over the counter medications and regular alcohol consumption.
It is important to note that anti-estrogen use may slightly reduce gains made during a steroid cycle, as many androgenic/anabolic steroids seem to exhibit their most powerful anabolic effects when accompanied by a sufficient level of estrogen (See: Aromatization ).This may be one reason why gains made with a strong aromatizable androgen like testosterone are usually more pronounced than those achieved with anabolic steroids that aromatizes to a lower (or no) degree. Therefore, it is usually advised to identify a specific need for tamoxifen citrate before committing to its use during a cycle. Many people, in fact, find the use of an anti-estrogen unnecessary, even when utilizing problematic compounds such as testosterone or methandrostenolone. Others, however, find they are troubled by water retention and gynecomastia even with milder (less estrogenic) drugs like Deca-Durabolin® and Equipoise®. The estrogenic response to steroid use is very individual, and may be influenced by factors such as age and body fat percentage (adipose tissue is a primary site of aromatization).
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