There is limited information available on the pharmacokinetics of oxymetholone.  It appears to be well-absorbed with oral administration .  Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT.  The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation .   The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone.  The elimination half-life of oxymetholone is unknown.  Oxymetholone and its metabolites are eliminated in the urine .  
Because the ultimate goal of a steroid cycle is to increase strength and muscle size, the associated spike in estrogen which accompanies steroids such as Testosterone is considered undesirable. In order to disassociate the two effects, two classes of drug are used. Medications such as Nolvadex or Clomid target the estrogen receptors. They make it more difficult for the estrogen to exert it’s influence within the body thus allowing the testosterone to act more freely. The second class is aromatase inhibitors such as Femara. They target the aromatase enzyme itself in order to prevent the production of estrogen in the first place. Sometimes, it’s not always clear which option you should go with or even what the differences are between the two. Lets clear that up a little.
In addition to Testosterone and Methandienone , Oxymetholone is one of the most powerful steroids for sale and therefore extremely popular among bodybuilders and athletes. The extremely fast effect of Oxymetholone on gains in muscle mass is so great that it is fairly easy to get 5 to 6 kilos in two weeks. The moderate to low androgenic effect in combination with the high anabolic effect gives an explosive growth in muscle mass that you will achieve with the use of Oxymetholone. Users of Oxymetholone also benefit from protective effect on the joints so that they can train extra heavily.