Most drugs of abuse are addictive. Addiction is a chronic, relapsing disease characterized by compulsive drug seeking and use despite negative consequences and by long-lasting changes in the brain. People who are addicted have strong cravings for the drug, making it difficult to stop using. Most drugs alter a person’s thinking and judgment, which can increase the risk of injury or death from drugged driving or infectious diseases (., HIV/AIDS, hepatitis) from unsafe sexual practices or needle sharing. Drug use during pregnancy can lead to neonatal abstinence syndrome, a condition in which a baby can suffer from dependence and withdrawal symptoms after birth. Pregnancy-related issues are listed in the chart below for drugs where there is enough scientific evidence to connect the drug use to negative effects. However, most drugs could potentially harm an unborn baby.
An assessment for an underlying cause of behavior is needed before prescribing antipsychotic medication for symptoms of dementia .  Antipsychotics in old age dementia showed a modest benefit compared to placebo in managing aggression or psychosis, but this is combined with a fairly large increase in serious adverse events. Thus, antipsychotics should not be used routinely to treat dementia with aggression or psychosis, but may be an option in a few cases where there is severe distress or risk of physical harm to others.  Psychosocial interventions may reduce the need for antipsychotics. 
In estimating the impacts on economic activity and employment from undoing these spending caps, we assume that the composition of discretionary spending is essentially unchanged by shifts in the level of spending. It is theoretically true that cuts to infrastructure spending could be less or more steep than overall spending cuts, but this is nearly impossible to forecast. Further, the discretionary spending cuts currently constituting the policy baseline in the United States (., the budget “sequester”) are across-the-board cuts to every category of discretionary spending, making the assumption that the composition of discretionary spending cuts will be unaffected by the level in fact consistent with current budget law.